【摘 要】
:
Objective:To evaluate the synergic effects of a novel oral supplement formulation,containing prebiotics,yeast β-glucans,minerals and silymarin (Silybum marianum),on lipid and glycidic metabolism,inflamma-tory and mitochondrial proteins of the liver,in con
【机 构】
:
Laboratory of Medical Investigation (LIM-26) ,Department of Surgery,University of Sao Paulo Medical
论文部分内容阅读
Objective:To evaluate the synergic effects of a novel oral supplement formulation,containing prebiotics,yeast β-glucans,minerals and silymarin (Silybum marianum),on lipid and glycidic metabolism,inflamma-tory and mitochondrial proteins of the liver,in control and high-fat diet-induced obese mice.Methods:After an acclimation period,32 male C57BL/6 mice were divided into the following groups:nonfat diet (NFD) vehicle,NFD supplemented,high-fat diet (HFD) vehicle and HFD supplemented.The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet (28 consecutive days).We then evaluated energy homeostasis,inflammation,and mito-chondrial protein expression in these groups of mice.Results:After four weeks of supplementation,study groups experienced reduced glycemia,dyslipidemia,fat,and hepatic fibrosis levels.Additionally,proliferator-activated receptor-x,AMP-activated protein kinase-1α,peroxisome proliferator-activated receptor y co-activator-1α,and mitochondrial transcription factor A expression levels were augmented;however,levels of inhibitor of nuclear factor-κB kinase sub-unit α and p65 nuclear factor-κB expression,and oxidative markers were reduced.Notably,the cortisol/C-reactive protein ratio,a well-characterized marker of the hypothalamic-pituitary-adrenal axis immune interface status,was found to be modulated by the supplement.Conclusion:We discovered that the novel supplement was able to modify different antioxidant,meta-bolic and inflammatory pathways,improving the energy homeostasis and inflammatory status,and con-sequently alleviated hepatic steatosis.
其他文献
目的:观察早期护理干预联合产后低频电流刺激预防产后尿潴留发生的临床疗效,探讨一种有效方法,以提高治疗效果,降低产后尿潴留发生率.方法:选取我院产科2019年3月~2020年9月收治的92例阴道分娩产妇,根据产后不同处理方法将其分为A组与B组,每组46例,A组予以尿潴留常规预防治疗,B组在A组的基础上予以早期护理干预联合产后低频电流刺激治疗,对比两组产妇的初次排尿时间、残余尿量、尿潴留发生率、尿路感染率以及产后尿潴留患者的治疗效果、尿管留置时间、膀胱功能恢复时间以及住院时间.结果:B组产妇的初次排尿时间、残
目的 建立大气PM2.5中铵离子的超声提取-连续流动分析测定方法.方法 将石英滤膜采集大气PM2.5中铵离子前用超纯水超声浸洗30 min的方式进行预处理,采集后的滤膜取1/4剪碎后经超纯水于25℃超声提取30 min,提取液以0.45 μm亲水性PTEE滤膜过滤,采用连续流动分析仪测定.结果 铵离子的质量浓度在0.02~5.00 mg/L内与其峰高呈线性关系,相关系数为0.9999.当采样体积为138 m3时,检出限为0.01 μg/m3,测定下限为0.04 μg/m3.以空白滤膜为基体进行加标回收试验
目的:探求中医针灸补泻法治疗静脉曲张的独特疗效.方法:运用《黄帝内经》“迎而泻之,随而补之”之针灸循经补泻理论泻实补虚.结果:静脉曲张症状得到治疗,气血得调,脏腑功能得到修复.其治疗方案不局限于局部,它更强调局部与整体的联系,如与脏腑、经络的联系等等.结论:本文通过梳理《黄帝内经》中提到的针灸补泻法治疗静脉曲张,从表里、虚实的角度探讨静脉曲张的病因及诊疗思路,以及配合西医治疗方面进行分析和实践,调理经脉,调和阴阳,减轻病痛.
骨伤科疾病种类繁多.中药外敷法是治疗骨伤科疾病的外治法之一,与中药内服法相比具有疗效良好、操作便捷、作用直接、价格低廉等特点.本文对中药外敷法进行了概述,并对其在骨伤科疾病治疗中的应用现状进行了综述.
目的:观察针刺督脉、夹脊穴对不随意运动型脑瘫患儿运动功能和核心肌力影响.方法:将71例不随意运动型脑瘫患儿随机分为治疗组(36例)和对照组(35例),对照组使用常规针刺,治疗组在常规针刺的基础上加用督脉及夹脊穴,观察两组治疗前后GMFM分数、核心肌表面肌电值变化.结果:治疗组治疗前后的GMFM分值、核心肌表面肌电值改善较对照组明显,差异有统计学意义(P<0.05).结论:针刺督脉及夹脊穴可改善不随意运动型脑瘫患儿核心肌力及粗大运动能力.
介绍临床采用隔药灸配合穴位埋线治疗薄型子宫内膜壁继发不孕案1则,认为隔药灸配合穴位埋线能够补益肝肾,调补冲任,疗效显著.
新九针疗法的核心思想是发挥多种不同针具及其针法的整体性与特异性治疗疾病.本文列举3个临床验案,根据疾病的不同时期,选择不同针具、针法相结合的治疗方法,望能给新针灸临床治疗提供有益的借鉴和启发.
痔病是肛肠疾病中的常见病、多发病,多表现为肛门肿物脱出或便血,严重影响人们的生活质量,保守治疗欠佳时手术是治疗痔病的关键.传统的外剥内扎术是迄今为止应用最广泛的术式之一,但其创面大、并发症多、愈合慢等缺点使部分临床工作者将其束之高阁,纷纷选择痔微创手术.不过单一的痔微创手术往往达不到理想疗效,尤其是合并明显外痔者,且吻合器手术价格较为昂贵.改良外剥内扎术不仅可以保留传统术式“简、便、效、廉”的优点,还能在一定程度上弥补传统术式的缺点,减少术后并发症、加快创面愈合、减轻患者痛苦、提高满意度,值得广大临床工作
Objective:This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches,including in vitro methods,as well as a well-defined nematode model,Caenorhabditis elegans.Methods:THP-R-SR012 decoction was selected from 23
外治疗法具有效果显著、相对安全、方便廉价等特点,受到广大患者和医务人员的青睐.但是受到政策、硬件设施、技术等因素的限制,外治疗法在发展过程中遇到一些困难,为了外治疗法更好地发展,笔者提出建设外治功能带的概念,形式上将各种外治疗法合理拆分到各个区域,管理层面建立高度统一的外治领导小组,全院从管理层到施术人员,高度重视,高度协同,高度理解,高度集约.在此基础上,笔者相信外治功能带的前景是美好的,其能最大限度地节约资源,使外治疗法更加专业化,进而更好地服务患者,并为外治中心的建立打好基础.