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间质性膀胱炎患者尿液中神经生长因子 (ＮＧＦ)常会升高。作者通过膀胱内灌注ＮＧＦ诱导制成膀胱过度活动症模型 ,评价Ａδ传入神经和Ｃ传入神经的重要性。实验共使用了 2 2只Ｗｉｓｔａｒ和8只Ｓｐｒａｇｕｅ Ｄａｗｌｅｙ成年雌鼠 ,均采用乌拉坦 1.2ｍｇ/ｋｇ皮下注射麻醉。
Patients with interstitial cystitis in the urine of nerve growth factor (NGF) often increased. The authors induced an overactive bladder model by intravesical instillation of NGF and evaluated the importance of Aδ afferent and C-afferent nerves. A total of 22 adult Wistar rats and 8 adult Sprague Dawley females were used and were anesthetized with subcutaneous injection of 1.2 mg / kg urethane.