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通过非环前体的分子内成环反应,可合成一类多取代苯,对这类产物进行结构鉴定,有助于了解整个反应历程和机理。但取代基增多,势必导致各结构因素变得复杂,难以从各芳碳的经验计算式去推测各取代基所处的相对位置,而以一般的光、波谱方法也较难获得这类结构信息。实验表明,核磁COLOC技术是确定这类产物各取代基相对位置较为合适的方法,本文以NMR技术对这类产物进行了结构鉴定,并讨论了COLOC技术在确定其各取代基相对位置中的作用;同时通过对产物的结构确认,讨论了产物取代基间的相互作用所导致其芳碳化学位移实测值与经验计算值之间的差异,以及含氟基团对邻位芳碳的碳氟间三键偶合作用。
Through intramolecular cyclization of non-cyclic precursors, a class of poly-substituted benzenes can be synthesized. Structural identification of these products can help to understand the whole reaction process and mechanism. However, the increase of substituents will inevitably lead to the complexity of each structural element, so it is difficult to infer the relative positions of the substituents from the empirical formulas of each aromatic carbon, and it is difficult to obtain such structural information by general light and spectral methods . Experiments show that the NMR COLOC technology is to determine the relative position of each substituent of these products is more appropriate method, this article NMR structures of these products were identified and discussed the role of COLOC technology in determining the relative position of each substituent role At the same time, by the confirmation of the structure of the product, the differences between the measured value of aromatic carbon chemical shift and the empirically calculated value due to the interaction between the product substituents are discussed, and the relationship between the fluorine- Three key coupling.