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目的研究环境内分泌干扰物双酚A(bisphenol A,BPA)与2岁以下婴幼儿女童乳房发育(permature thelarche,PT)的关系。方法选择6月~2岁PT 40例,正常同龄女童32例,利用高效液相色谱串联质谱法(HPLC-MSMS)进行血清BPA浓度测定,同时运用化学发光法进行血清性激素浓度:卵泡刺激素(follicule-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)、泌乳素(prolactin,PRL)测定,比较两组差异及分析BPA与性激素之间相关性。结果6月~2岁婴幼儿女童PT组血清BPA检出率及浓度均显著高于对照组(P均<0.01)。两组血清FSH,PRL浓度差异无统计学意义(P>0.05),PT组血清E2浓度高于对照组(P<0.05),PT组血清LH浓度高于对照组(P<0.01)。两组血清BPA浓度与FSH浓度、PRL浓度无相关性(P>0.05)。血清BPA浓度与E2和LH浓度有相关性(P<0.01)。结论 6月~2岁婴幼儿女童存在BPA的暴露;BPA暴露可能是6月~2岁婴幼儿女童出现PT的原因之一。6月~2岁婴幼儿女童BPA的暴露可能影响LH及E2的分泌。
Objective To study the relationship between environmental endocrine disruptor bisphenol A (BPA) and breast milk development (permature thelarche, PT) in infants under 2 years of age. Methods 40 cases of PT were selected from June to 2 years old and 32 cases of normal girl with same age. Serum BPA concentration was determined by high performance liquid chromatography-tandem mass spectrometry (HPLC-MSMS). Serum sex hormone concentrations were determined by chemiluminescence method: follicle stimulating hormone follicule-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and prolactin (PRL) were measured. The differences between the two groups were analyzed and the correlation between BPA and sex hormones was analyzed. Results The detection rate and concentration of serum BPA in PT group were significantly higher than those in control group (P <0.01). There was no significant difference in serum FSH and PRL concentrations between the two groups (P> 0.05). Serum E2 concentration in PT group was higher than that in control group (P <0.05). Serum LH concentration in PT group was higher than that in control group (P <0.01). Serum BPA concentration in both groups had no correlation with FSH concentration and PRL concentration (P> 0.05). Serum BPA concentration was correlated with E2 and LH concentrations (P <0.01). Conclusions BPA exposure exists in infants and young children aged 6 months to 2 years. BPA exposure may be one of the causes of PT in infants and young children aged 6 months to 2 years old. Exposure to BPA in infants and young children aged 6 to 2 years may affect the secretion of LH and E2.