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园丝氨酸(Cyclosrin)是1955年新发现的抗菌素,抗菌谱较广,对革兰氏阳性及阴性细菌及结核杆菌均有一定的抑制作用,1955年 Epstein 氏首先报告对肺结法病的治疗。国內1960年徐昌文等报告5例,有一定疗效。从1959年来.我院对11例慢性重症肺结核患者以园丝氨酸与异芋肼等药并用,发现9例有不同程度的毒性反应。一例女性患者,经常有高热、盗汗、失眠症状,服用园丝氨酸(法国“Roche”药厂出产)250毫克每日四次,并服用异芋肼100毫克,每日三次。第二天双手振颤、思睡,至第八天高热消退,
Cyclosrin is a newly discovered antibiotic in 1955 with a broad antimicrobial spectrum. It has certain inhibitory effects on Gram-positive and -negative bacteria and Mycobacterium tuberculosis. In 1955, Epstein first reported the treatment of pulmonary tuberculosis. Domestic Xuchang Wen in 1960 reported 5 cases, have a certain effect. From 1959. In our hospital, 11 patients with chronic severe pulmonary tuberculosis were treated with Parkinson’s serine and other drugs, and found that 9 patients had different degrees of toxicity. A female patient often has symptoms of fever, night sweats, insomnia, taking 250 mg of parkine (produced by French “Roche”) four times a day and taking 100 mg of canola three times daily. The second day both hands tremble, think of sleep, high fever subsided to the eighth day,