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探讨ＮＦ２基因缺失在散发脑膜瘤发病中的意义及其与不同组织学类型的相关性，为脑膜瘤分子水平分类提供依据。选取目前发现的与ＮＦ２基因连锁最为紧密的一个ＤＮＡ多态标记（Ｄ２２Ｓ２６８），就其在５６例散发脑膜瘤中的杂合性缺失（ｌｏｓｓｏｆｈｅｔｅｒｏｚｙｇｏｓｉｔｙ，ＬＯＨ）进行研究。Ｄ２２Ｓ２６８在散发脑膜瘤中的ＬＯＨ率高达５９．５％（２５／４２），其ＬＯＨ率在纤维型脑膜瘤和合体细胞型脑膜瘤中存在显著差异，而在Ⅰ、Ⅱ、Ⅲ级脑膜瘤中不存在明显差异。ＮＦ２基因的失活可能是散发脑膜瘤发生中的早期事件，以缺失为主；与在纤维型脑膜瘤中不同，ＮＦ２基因的缺失在合体细胞型脑膜瘤发生中可能不起主要作用。
To explore the significance of deletion of NF2 gene in the pathogenesis of disseminated meningiomas and its correlation with different histological types, and provide basis for molecular level classification of meningiomas. We selected a DNA polymorphism marker (D22S268) that was most closely linked to the NF2 gene and studied the loss of heterozygosity (LOH) in 56 cases of meningioma. D22S268 has an LOH rate as high as 59.5% (25/42) in sporadic meningiomas, and its LOH rate is significantly different between fibroid meningioma and syncytial meningiomas, but in grade I, II, and III meningiomas. There is no significant difference. The inactivation of NF2 gene may be an early event in the distribution of meningioma, and the loss is predominant. Unlike in fibroid meningioma, the deletion of NF2 gene may not play a major role in the development of syncytial meningiomas.