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一、概况近十年来国外文献对青年女性肝炎病人进行了较系统的研究,即病程中伴有高丙种球蛋白血症及明显内分泌障碍者,则暗示有内脏狼疮。 1950年(?)报告六例青年女性患严重的慢性肝脏疾病,有明显肝肿大,血管痣,血沉增快,丙种球蛋白升高,福尔马林试验强阳性,并对激素治疗有良好反应。1951-1956年作者报告26例青年女性进行性肝硬变的病例:临床表现肝脾肿大,周期性发烧,关节损害,内分泌紊乱(闭经、痤疮、多毛症、肥胖、月圆脸)。高丙种球蛋白血症(高达9.4克％)及明显的肝细胞浸润。1955年Mackay报告19例具有上述改变并有全身性红斑狼疮表现而在所有病人血液内均以查到LE细胞为确诊依据。其它学者亦持同样见解。所谓《狼疮样肝炎》,1955年Joske首先报告2例活动性慢性肝炎病例中发现狼疮样细胞现象,并
I. Overview In the past ten years, foreign literature has conducted a systematic study of young women with hepatitis, which means that there is visceral lupus in patients with hypergammaglobulinemia and obvious endocrine disorders. In 1950 (?) Reported six young women suffering from severe chronic liver disease, significant hepatomegaly, vascular nevus, erythrocyte sedimentation rate, elevated gamma globulin, strong positive formalin test, and good hormone therapy reaction. The authors report from 1951 to 1956 on 26 cases of progressive cirrhosis in young women: clinical manifestations of hepatosplenomegaly, recurrent fever, joint damage, endocrine disorders (amenorrhea, acne, hirsutism, obesity, full moon face). Hypergammaglobulinemia (up to 9.4 g%) and significant hepatocellular infiltration. 1955 Mackay reported 19 patients with the above changes and the performance of systemic lupus erythematosus in all patients were found in the LE cells for the diagnosis. Other scholars hold the same view. The so-called “lupus-like hepatitis”, 1955 Joske first reported 2 cases of active chronic hepatitis found in cases of lupoid cells, and