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目的探讨血清肿瘤标志物癌胚抗原(CEA)、糖类抗原153(CA15-3)和糖类抗原125(CA125)对乳腺癌的诊断价值。方法采用电化学发光法分别检测60例乳腺癌患者(乳腺癌组)和50例健康体检妇女(对照组)血清CEA、CA15-3、CA125水平。结果血清CEA、CA15-3和CA125血清水平乳腺癌组显著高于健康对照组(P<0.05);三项指标联检灵敏度显著高于各单项指标的检测(P<0.05)。结论血清CEA、CA15-3和CA125联合检测可提高乳腺癌的阳性诊断率,值得推广应用。
Objective To investigate the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 153 (CA15-3) and carbohydrate antigen 125 (CA125) in breast cancer. Methods The serum levels of CEA, CA15-3 and CA125 in 60 patients with breast cancer (breast cancer group) and 50 healthy women (control group) were detected by electrochemiluminescence. Results Serum CEA, CA15-3 and CA125 levels in serum of breast cancer patients were significantly higher than those in healthy controls (P <0.05). Sensitivity of three indicators was significantly higher than that of single indicators (P <0.05). Conclusion Serum CEA, CA15-3 and CA125 combined detection can improve the positive diagnosis rate of breast cancer, which is worth popularizing and applying.