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体外培养的植入前期小鼠胚胎在2-细胞阶段的晚G_2期用X射线及中子进行辐照。两种射线在非常低帮量时都诱发微核,X线辐照后,第一个和第二个细胞周期中微核形成的动态取决于辐射剂量和分裂延迟的程度。甚至在照射后第三次和更晚一些的有丝分裂之后,似乎还有新的微核形成。本文讨论了各种剂量-效应曲线图形及两种辐射引起的微核形成机制。一、引言毫无疑问,由电离辐射引起的遗传突变是重要的,对于辐射防护来说这种低剂量效应相当有意义。Heddle和Schmid所述的微核检验方法应用渐增,特别是应用于化学诱变领域,微核检验是遗传损伤的一
In vitro preimplantation mouse embryos were irradiated with X-rays and neutrons in the late G2 phase of the 2-cell stage. Both rays induce micronuclei at very low doses, and the dynamics of micronuclei formation in the first and second cell cycles following X-ray irradiation depend on the extent of radiation dose and split delay. There appears to be new micronucleus formation even after the third and later mitoses after irradiation. This article discusses the various dose-response curve patterns and micronucleus formation mechanisms caused by both radiation. I. INTRODUCTION There is no doubt that genetic mutations caused by ionizing radiation are important and this low-dose effect is quite significant for radiation protection. The micronucleus test methods described by Heddle and Schmid are increasingly used, especially in the field of chemical mutagenesis, and micronucleus test is one of genetic damage