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本实验收集经病理确诊为肺鳞癌的标本67例，应用免疫组织化学技术检测到P53蛋白的阳性率为61．2％。同时结合聚合酶链反应检测人乳头状瘤病毒（HPV）感染，检出感染标本10例（14．9％），其中4例伴有P53蛋白阳性。表明肺鳞癌中存在着HPV感染。本文结果也提示，P53基因突变与肺鳞癌的分化程度无联系。
Sixty-seven specimens of pathologically confirmed lung squamous cell carcinoma were collected in this experiment. The positive rate of P53 protein detected by immunohistochemical technique was 61.2%. At the same time, human papillomavirus (HPV) infection was detected by polymerase chain reaction. Ten (14.9%) cases of infection were detected, and 4 of them were positive for P53 protein. It shows that HPV infection exists in lung squamous cell carcinoma. The results of this study also suggest that there is no relationship between P53 gene mutation and the degree of differentiation of lung squamous cell carcinoma.