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目的:探讨整合素连接激酶(ILK)与喉鳞状细胞癌(LSCC)发生、发展的关系。方法:应用RT-PCR方法,检测64例LSCC标本(LSCC组)和10例正常喉黏膜组织(对照组)中ILK mRNA的表达。结果:LSCC组ILK mRNA表达(0.644±0.098)明显高于对照组(0.032±0.026),差异有统计学意义(P<0.05);ILK mRNA在有淋巴结转移组织中的表达(0.867±0.247)明显高于无淋巴结转移组织(0.389±0.199),差异有统计学意义(P<0.05)。随着LSCC临床T分期的发展,ILK mRNA的表达均相应升高,但相邻两组间差异无统计学意义(均P>0.05)。结论:ILK的高表达对LSCC的形成和发展起重要作用;ILK mRNA高表达与LSCC淋巴结转移密切相关,提示ILK可能成为预测LSCC转移和预后的生物学指标。
Objective: To investigate the relationship between integrin-linked kinase (ILK) and the occurrence and development of laryngeal squamous cell carcinoma (LSCC). Methods: The expressions of ILK mRNA in 64 LSCC specimens (LSCC group) and 10 normal laryngeal mucosa tissues (control group) were detected by RT-PCR. Results: The expression of ILK mRNA in LSCC group (0.644 ± 0.098) was significantly higher than that in control group (0.032 ± 0.026), the difference was statistically significant (P <0.05). The expression of ILK mRNA in lymph node metastasis (0.867 ± 0.247) was significantly (0.389 ± 0.199), the difference was statistically significant (P <0.05). With the development of clinical staging of LSCC, the expression of ILK mRNA increased correspondingly, but there was no significant difference between two adjacent groups (all P> 0.05). Conclusion: The high expression of ILK plays an important role in the formation and development of LSCC. The high expression of ILK mRNA is closely related to lymph node metastasis in LSCC, suggesting that ILK may be a biological indicator for predicting the metastasis and prognosis of LSCC.