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目的 分析2002～2011年中国肝癌住院患者日均医疗费用情况及变化趋势.方法 基于国家重大公共卫生服务专项项目—城市癌症早诊早治项目, 收集全国12个省份的多中心回顾性调查数据, 分析2002～2011年我国肝癌患者日均医疗诊治花费及影响因素.结果 共纳入11 045例肝癌患者, 平均年龄55岁, 平均住院日16.76天.肝癌患者的平均日均诊治费用为1 251元[95％CI (1 236, 1 266) ], 且在不同地区 (东部:1 356元;中部:1 209元;西部:1 068元) 、不同医院类型 (综合医院:1 341元, 专科医院:1 213元) 和不同医院等级 (三甲医院:1 293元, 非三甲医院:805元) 间差异均存在统计学意义 (P＜0.05).对不同分期肝癌患者而言, Ⅰ期患者日均费用为1 253元, Ⅱ期为1 169元, Ⅲ期为1 167元, Ⅳ期为1 092元 (P＜0.05).10年趋势分析显示, 20022011年间的肝癌日均费用由1 079元[95％CI (1 021, 1 136) ]增长至1 549元[95％CI (1 486, 1 613) ], 平均增长速度为3.69％, 增长速度从2007年起尤为明显.不同亚组分析提示, 不同地区和医院级别的增长模式有较明显区别, 不同治疗方案导致的增长趋势可能存在差别.结论 我国肝癌日均诊治费用逐年增长, 且存在地区和医院级别差异, 结合次均住院日变化数据可为我国肝癌防治方案或策略的经济性评价提供参考数据.“,”Objectives To analyze the average daily medical expenditures for primary liver cancer in China from 2002 to 2011. Methods This study employed retrospective survey on multiple centers from 12 provinces and cities in China from 2002 to 2011, based on the continuous data from the Cancer Screening Program in the Urban China Project.The average daily medical expenditures of primary liver cancer patients and influencing factors were analyzed. Results A total of 11 045 liver cancer patients from 12 provinces and cities were included, with an average age of 55 and an average duration of hospitalization of 16.76 days. The average daily medical expenditures of liver cancer patients during the 10 years was 1 251 yuan (95％CI 1 236 to 1 266). The average daily medical expenditures was significantly different in regions (1 356 yuan in the east region, 1 209 yuan in the middle region and 1 068 yuan in the west region), types of hospital (1 341 yuan in general hospitals, 1 213 yuan in specialized hospitals) and hospital levels (1 293 yuan in 3 A grade hospital, 805 yuan in non-3 A grade hospital) (P＜0.05). The average daily medical expenditures were 1 253 yuan for stage Ⅰ, 1 169 yuan for stage Ⅱ, 1 167 yuan for stageⅢ and 1 092 yuan for stage Ⅳ (P＜0.05). From 2002 to 2011, the average daily medical expenditures of hospitalization increased from 1 079 yuan (95％CI 1 021 to 1 136) to 1 549 yuan (95％CI 1 486 to 1 613), with an average growth rate of 3.69％. Since 2007, a continuous growth was observed. Subgroup analysis suggested there were obvious differences in growth patterns between different regions and hospitals, as well as differences between various treatments. Conclusions The average daily medical expenditures of liver cancer in China had been increasing from 2002 to 2011 and there were significant differences between various regions and hospital levels. Combined with data on the change of duration of hospitalization, it can provide reference for the economic evaluation of the nation's prevention and treatment policies for liver cancer.