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背景青少年肌阵挛性癫痫(Juvenile myoclonic epilepsy,JME)的特征为觉醒后肩部和手臂肌肉不受控制的肌阵挛抽搐,以及双侧同步的4~6Hz的棘-慢复合波,常常开始于儿童时期。丙戊酸钠由于其作用的广谱性,被普遍认为是JME一线治疗药物。然而,仍有20%的JME经丙戊酸钠治疗后无法达到满意控制。托吡酯是一种新型广谱抗癫痫药物(AEDs)。有研究表明,托吡酯单药治疗
BACKGROUND Juvenile myoclonic epilepsy (JME) is characterized by uncontrolled myoclonus convulsions of the shoulders and arm muscles after arousals, and bilateral synchronous 4- to 6-Hz spine-slow complexes often begin In childhood. Sodium valproate is generally considered the first-line treatment for JME due to its broad spectrum of effects. However, there is still 20% of JME unable to achieve satisfactory control after treatment with sodium valproate. Topiramate is a new broad-spectrum antiepileptic drug (AEDs). Studies have shown that topiramate monotherapy