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表皮生长因于受体（EGFR）是一单跨膜糖蛋白，与细胞的增殖、转化有关。本文采用免疫组化ABC法检测8例正常颊粘膜上皮及40例颊粘膜鳞癌中EGFR的表达状况，结果显示：EGFR在颊癌组织中呈异质性表达，其阳性率明显高于正常颊粘膜组织（P＜0．05）；EGFR表达状况与颈淋巴结转移及预后间存在相关关系（P＜0．05）。EGFR（＋）表达者多数伴有颈淋巴结转移，预后差。以上结果说明，EGFR在颊癌组织中的表达水平，可作为评估颊癌细胞增殖状态，颈淋巴结转移情况及患者预后的一项参考指标。
Epidermal growth due to the receptor (EGFR) is a single transmembrane glycoprotein, and cell proliferation, transformation. The immunohistochemical ABC method was used to detect the expression of EGFR in 8 cases of normal buccal mucosa epithelium and 40 cases of buccal mucosa squamous cell carcinoma.The results showed that the expression of EGFR was heterogeneous in buccal carcinoma and the positive rate was significantly higher than that of normal buccal Mucosa (P <0.05). There was a correlation between EGFR expression and cervical lymph node metastasis and prognosis (P <0.05). The majority of EGFR (+) expressed cervical lymph node metastasis, the prognosis is poor. These results indicate that the expression of EGFR in buccal carcinoma can be used as a reference index to evaluate the proliferation status, cervical lymph node metastasis and patient prognosis.