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查阅近年来有关肺癌相关内源性激素及其受体研究的文献,将整理与肺癌密切相关的几种内源性多肽类激素如血管紧张素及其受体、雌激素及其受体、胰岛素样生长因子及其受体、生长抑素及其受体与胸腺激素等进行综合分析。结果显示调节肺癌的发生和发展与内源性激素调节紊乱有一定的关系,血管紧张素及其受体、雌激素及其受体、胰岛素样生长因子及其受体、生长抑素及其受体、胸腺激素均有抑制肺癌生长的作用。寻找和设计抗肺癌药物乃至抗肿瘤药物,内源性寡肽类激素及其类似物将是一个重要的考虑方向。研究与肺癌发生和发展相关的内源性激素及其调控网络,对于设计和研发抗肺癌药物具有及其重要的参考价值。
Read the literature on lung cancer-associated endogenous hormones and their receptors in recent years. We will sort out several endogenous peptide hormones such as angiotensin and its receptor, estrogen and its receptor, and insulin Comprehensive analysis of growth factors and their receptors, somatostatin and its receptors and thymus hormones. The results show that the regulation of the occurrence and development of lung cancer has some relationship with endogenous hormone regulation disorders, angiotensin and its receptor, estrogen and its receptor, insulin-like growth factor and its receptor, somatostatin and its receptor Both thymic hormones inhibit the growth of lung cancer. Finding and designing anti-lung cancer drugs and even anti-tumor drugs, endogenous oligopeptide hormones and their analogues will be an important consideration. The study of endogenous hormones and their regulatory networks related to the occurrence and development of lung cancer has important reference value for the design and development of anti-lung cancer drugs.