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目的:观察银杏内酯对拟Alzheimer病大鼠学习、记忆的影响。方法:大鼠海马背侧微量注射0.4mmol/LOkadiacAcid(OA)0.6μl,每两天一次,连续三次,造模。银杏内酯治疗组与模型制作同时开始,每只每天腹腔注射银杏内酯(50mg/kg),连续注射21天。海马背侧首次微量注射20天后,测试各组大鼠空间学习记忆能力,大鼠海马冠状切片HE染色。结果:银杏治疗组较模型组大鼠空间学习记忆能力明显增强,HE染色显示银杏内酯治疗组神经元变性及坏死较模型组减少明显。结论:银杏内酯可提高拟Alzheimer病模型鼠的学习、记忆能力。
Objective: To observe the effects of ginkgolide on learning and memory of Alzheimer’s disease rats. METHODS: Rat hippocampal microinjection 0.4mmol/L OkadiacAcid (OA) 0.6μl, once every two days, three times in a row, modeling. Ginkgolide treatment group and model production started at the same time. Each ginkgo lactone (50 mg/kg) was injected intraperitoneally for 21 consecutive days. After 20 days of microinjection into the hippocampus of the hippocampus, the spatial learning and memory abilities of the rats in each group were tested and HE staining was performed on coronal sections of the hippocampus of the rats. Results: The spatial learning and memory ability of the Ginkgo biloba group was significantly higher than that of the model group. HE staining showed that the neuron degeneration and necrosis in the ginkgolide group was significantly less than that in the model group. Conclusion: Ginkgolide can improve the learning and memory ability of model mice with Alzheimer’s disease.