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目的:观察吸入伊洛前列素治疗先天性心脏病术后肺动脉高压患儿的血液流变学指标变化。方法:随机选择10例术后未吸入伊洛前列素患儿,10例术后24 h吸入伊洛前列素患儿,年龄0～14岁。运用血液流变学仪检测吸入伊洛前列素前后3项血液流变学指标。结果:与未吸入伊洛前列素组相比,吸入伊洛前列素后24 h患儿红细胞聚集性和血液屈服应力明显降低,红细胞变形指数增高。未吸入组术后0 h与24 h血液流变学指标差异均无统计学意义。结论:吸入伊洛前列素能明显改善儿童先天性心脏病肺动脉高压的血液流变学性状。
Objective: To observe the changes of hemorheology indexes in children with pulmonary hypertension after the inhalation of iloprost. Methods: Ten patients were randomized to receive iloprost without surgery, and 10 patients with iloprost were enrolled in the study. The age ranged from 0 to 14 years. Hemorrheology was used to detect 3 hemorheological indexes before and after inhaling iloprost. RESULTS: Compared with those without inhalation of iloprost, the erythrocyte aggregation and blood yield stress were significantly decreased and erythrocyte deformability index increased 24 h after inhalation of iloprost. There was no significant difference in hemorrheological indexes between 0 h and 24 h after non-inhalation. Conclusion: Inhaling iloprost can significantly improve the hemorheology of children with congenital heart disease with pulmonary hypertension.