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目的:探讨血清骨保护素(OPG),骨形态发生蛋白-7(BMP-7)和前列腺特有抗原(PSA)水平在前列腺癌(PCa)患者中的变化及其临床意义。方法:选取PCa患者65例和同期健康体检者65例,采用ELISA法测定血清OPG、BMP-7和PSA水平。结果:前列腺癌组血清OPG、BMP-7和PSA水平较正常对照组明显升高,且前列腺癌骨转移组OPG、BMP-7水平高于无骨转移组;随着Gleason分级升高,OPG、BMP-7和PSA表达量均有升高趋势。结论:血清OPG、BMP-7和PSA与PCa关系密切,参与了PCa的发生和发展,血清OPG、BMP-7可能为诊断前列腺癌骨转移的良好指标。
Objective: To investigate the changes of serum osteoprotegerin (OPG), bone morphogenetic protein-7 (BMP-7) and prostatic specific antigen (PSA) in patients with prostate cancer (PCa) and its clinical significance. Methods: Sixty-five PCa patients and 65 healthy controls were enrolled in this study. Serum levels of OPG, BMP-7 and PSA were measured by ELISA. Results: The levels of OPG, BMP-7 and PSA in prostate cancer group were significantly higher than those in normal control group, and the levels of OPG and BMP-7 in prostate cancer group were higher than those in non-bone metastasis group. With Gleason grading, BMP-7 and PSA expression increased. CONCLUSIONS: Serum OPG, BMP-7 and PSA are closely related to PCa and are involved in the occurrence and development of PCa. Serum OPG and BMP-7 may be good indicators for diagnosing bone metastasis of prostate cancer.