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[目的]调查分析我省小儿原发性IgA肾病的临床与病理特点。[方法]汇总我省6所医院近10年来经肾穿刺活检确诊为小儿原发性IgA肾病的住院患儿73例的临床资料进行回顾性分析。[结果]小儿原发性IgA肾病占肾穿刺活检病例总数的6.82%(73/1070)。10～14岁年龄组所占比例最大(67.1%),男女比2.65:1。临床表现多样,以孤立性血尿(31.5%)和肾病综合征(28.8%)多见;病理分型以Ⅲ级最多(57.5%),沉积类型以IgA+M+G(+C3)型最常见(58.9%),无发展为肾功能不全。[结论]小儿原发性IgA肾病以学龄期多见,男多于女,临床表现以单纯性血尿和肾病综合征多见,免疫沉积类型以IgA+M+G(+C3)为主。对小儿原发性IgA肾病,主张早期诊断并干预治疗。
[Objective] To investigate the clinical and pathological features of pediatric primary IgA nephropathy in our province. [Methods] The clinical data of 73 hospitalized children diagnosed as primary IgA nephropathy by renal biopsy in 6 hospitals in our province during the past 10 years were retrospectively analyzed. [Results] Children with primary IgA nephropathy accounted for 6.82% (73/1070) of the total number of renal biopsy cases. The age group 10 to 14 accounted for the largest proportion (67.1%), male to female ratio 2.65: 1. The clinical manifestations were diverse, with isolated hematuria (31.5%) and nephrotic syndrome (28.8%). The most common pathological type was grade Ⅲ (57.5%). The most common type of deposition was IgA + M + G (58.9%), no development of renal insufficiency. [Conclusion] Primary IgA nephropathy in children is more common in school age, more men than women. The clinical manifestations are more common in simple hematuria and nephrotic syndrome. The types of immune deposition are mainly IgA + M + G (+ C3). Primary IgA nephropathy in children, advocating early diagnosis and intervention.