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心血管疾病严重威胁人类健康。有关心血管疾病的研究一直是基础医学的一个重点研究方向。随着遗传学研究的发展,曾被认为无用的非编码基因序列越来越受到广大研究者们的关注。占非编码RNA(ncRNA)大多数的长非编码RNA(lncRNA)的相关研究正在兴起。虽然目前对lncRNA的研究尚处于起步阶段,但已有不少证据表明lncRNA与心血管疾病有着密切关系。本文重点介绍lncRNA的功能和特点,并在现有研究的基础上对lncRNA与心血管疾病的关系作进一步阐述。
Cardiovascular diseases pose a serious threat to human health. Research on cardiovascular diseases has been a focus of research in basic medicine. With the development of genetics, more and more researchers have been concerned about the non-coding gene sequences that have been considered useless. Related research on long non-coding RNA (lncRNA), which accounts for the majority of noncoding RNAs (ncRNAs), is on the rise. Although the current research on lncRNA is still in its infancy, there is a lot of evidence that lncRNA is closely related to cardiovascular diseases. This article focuses on the function and characteristics of lncRNA, and further elaborates the relationship between lncRNA and cardiovascular disease based on the existing research.