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1936年,Warren和Sommer首先报道1例乳腺癌放射治疗后发生的肉瘤,该患者于照射后24年发生胸壁纤维肉瘤及皮肤表皮癌。不久,Hatcher又报道1例乳腺癌照射后诱发的骨肉瘤。本文对爱丁堡西部总院临床肿瘤科1954~1965年收治的乳腺癌放射治疗后诱发骨肉瘤4例患者作了回顾性分析。例1:53岁,女性,左侧乳腺癌T_2No,1964年5月行左侧单纯乳房切除术。1964年6月术后放射治疗,2MeV范德格喇夫加速器,用标准的MC
In 1936, Warren and Sommer first reported a case of sarcoma that occurred after radiation therapy for breast cancer. This patient developed a fibrosarcoma of the chest wall and skin epidermoid carcinoma 24 years after irradiation. Soon, Hatcher reported one case of osteosarcoma induced by irradiation of breast cancer. In this paper, we retrospectively analyzed 4 cases of osteosarcoma induced by radiotherapy of breast cancer treated in the Department of Clinical Oncology of Edinburgh General Hospital in Western Department from 1954 to 1965. Example 1: 53-year-old female, left breast cancer T_2No, left mastectomy in May 1964. June 1964 postoperative radiotherapy, 2 MeV van der Lager accelerator, with standard MC