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目的观察真空小梁成形术(PNT)对国人原发性开角型青光眼(POAG)及高眼压症患者的降眼压效果。设计前瞻性病例系列。研究对象北京同仁医院2008年11月至2009年2月就诊的POAG及高眼压症患者30例(30眼)。方法入选患者进行眼科一般检查、前房角镜及Humphrey视野检查,测量眼压(压平眼压计)。患者单眼或双眼进行PNT1000型治疗仪(Oph-thalmic International公司产)治疗。治疗后1小时、1天、1周、2周、1个月、2个月复查。首次治疗后第7天重复治疗一次。单眼治疗者选治疗眼,双眼者随机选1眼,进行重复测量的方差分析。主要指标眼压。结果30例患者治疗前眼压(23.2±5.3)mmHg,平均应用局部降眼压药物1.47种(0～5种),治疗后1天、1周、2周、1个月、2个月各时间点眼压分别为(20.0±5.0)mmHg、(19.8±3.8)mmHg、(19.7±4.0)mmHg、(19.3±3.9)mmHg、(19.8±4.0)mmHg,眼压下降幅度分别为3.2mmHg、3.4mmHg、3.5mmHg、3.9mmHg、3.4mmHg,各时间点较治疗前眼压差异有统计学意义(P均<0.001)。23例(83%)治疗后眼压下降≥15%。结论本文的短期小样本研究显示,真空小梁成形术可安全有效地降低POAG及高眼压症患者的眼压。
Objective To observe the hypotensive effect of vacuum trabeculectomy (PNT) on patients with primary open angle glaucoma (POAG) and ocular hypertension in our country. Design prospective case series. Participants Beijing Tongren Hospital from November 2008 to February 2009 POAG and ocular hypertension in 30 patients (30 eyes). Methods Selected ophthalmic general examination, gonioscopy and Humphrey visual field examination, intraocular pressure (pressure tonometer). Patient monocular or binocular PNT1000 treatment instrument (Oph-thalmic International) treatment. 1 hour, 1 day, 1 week, 2 weeks, 1 month, 2 months after treatment. Treatment was repeated on day 7 after the first treatment. Monocular treatment selected eye treatment, eyes were randomly selected 1 eye, repeated measures of variance analysis. The main indicators of intraocular pressure. Results The 30 patients had an intraocular pressure (23.2 ± 5.3) mmHg before treatment, and an average of 1.47 kinds (0 ~ 5) of local intraocular hypotensive agents were used. One day, one week, two weeks, one month and two months after treatment The intraocular pressure at the time point was (20.0 ± 5.0) mmHg, (19.8 ± 3.8) mmHg, (19.7 ± 4.0) mmHg, (19.3 ± 3.9) mmHg and (19.8 ± 4.0) mmHg respectively. The intraocular pressure drops were 3.2mmHg, 3.4 mmHg, 3.5mmHg, 3.9mmHg, 3.4mmHg. There was significant difference in the intraocular pressure before treatment at each time point (all P <0.001). Twenty-three patients (83%) experienced a reduction in intraocular pressure by ≥15%. Conclusions This short-term small sample study shows that vacuum trabeculoplasty can safely and effectively reduce intraocular pressure in patients with POAG and ocular hypertension.