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[目的]检测乙型肝炎患者的乙型肝炎病毒血清标志物、前S1抗原及HBV-DNA和ALT、AST的水平,探讨其相关性及对乙肝患者诊断和治疗的临床意义。[方法]测定HBV-M及前S1抗原采用酶联免疫吸附试验法,检测HBV-DNA采用荧光定量聚合酶链反应。[结果]Pre-S1Ag在乙型肝炎e抗原(HBeAg)阳性和阴性患者的检出率差异有统计学意义,Pre-S1Ag阳性和阴性的患者ALT、AST异常率差异有统计学意义。[结论]HBVPreS1-Ag与HBeAg之间具有高度相关性,与HBV-DNA有较好的一致性,与肝功能损害密切相关。
[Objective] To detect the serum hepatitis B virus serum markers, pre-S1 antigen, HBV-DNA, ALT and AST levels in patients with hepatitis B, and to explore its correlation and its clinical significance in diagnosis and treatment of hepatitis B patients. [Method] The levels of HBV-M and pre-S1 antigen were determined by enzyme-linked immunosorbent assay (ELISA), and the detection of HBV-DNA by fluorescence quantitative polymerase chain reaction. [Results] The detection rate of Pre-S1Ag in HBeAg-positive and -negative patients was statistically significant, and the difference of ALT and AST abnormalities in patients with Pre-S1Ag positive and negative was statistically significant. [Conclusion] HBV PreS1-Ag is highly correlated with HBeAg and has good consistency with HBV-DNA, which is closely related to liver dysfunction.