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为探讨白质疏松（ＬＡ）病人ＬＡ区域和皮质部位的局部脑血流（ｒＣＢＦ）变化及与痴呆的关系，对２４例伴有ＬＡ〔ＬＡ（＋）〕、２５例无ＬＡ〔ＬＡ（－）〕的皮质下多发性脑梗塞病人及１０例正常对照者行脑血流ＳＰＥＣＴ显像，并与智能评分进行相关分析。结果：ＬＡ（＋）组与正常组相比，额叶、颞叶、顶叶、ＬＡ区域ｒＣＢＦ显著降低（ｔ＝２１２～２５４，Ｐ＜００５）；与ＬＡ（－）组相比，额叶和顶叶皮质、ＬＡ区域ｒＣＢＦ显著减少（ｔ＝２１１～２６０，Ｐ＜００５）；ＬＡ（＋）组长谷川智能评分与额叶皮质、ＬＡ区域ｒＣＢＦ变化呈显著正相关（ｒ＝０７６５，Ｐ＜００１和ｒ＝０４３９，Ｐ＜００５）。结果表明，伴ＬＡ的多发性脑梗塞病人，ＬＡ区和皮质区域存在广泛血流灌注不足，持续的低灌注状态可引起脑功能低下，并与痴呆的程度有一定关系；脑血流ＳＰＥＣＴ显像具有独特优势和价值。
To investigate the changes of regional cerebral blood flow (rCBF) in LA and cortical areas and the relationship with dementia in patients with leukoaraiosis (LA), 24 patients with LA [LA (+)] and 25 without LA (- ] Patients with subcortical cerebral infarction and 10 normal control subjects underwent cerebral blood flow SPECT imaging and correlation analysis with intelligent score. Results: Compared with normal group, rCBF in frontal lobe, temporal lobe, parietal lobe and LA were significantly decreased in LA (+) group (t = 212 ~ 254, P <005) Compared with the control group, rCBF in frontal and parietal cortex and LA were significantly decreased (t = 211 ~ 260, P <005) There was a significant positive correlation between changes of rCBF (r = 0765, P <001 and r = 0439, P <005). The results showed that patients with multiple cerebral infarction with LA had extensive perfusion in the LA and cortex regions, and persistent hypoperfusion could cause brain dysfunction and have a certain relationship with the degree of dementia. Cerebral blood flow SPECT imaging Has unique advantages and values.