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为探讨大剂量激素对脑创伤后脑微循环及血液流变性的影响，将２４只家兔随机等分为３组：标准对照组、损伤对照组和地塞米松治疗组。分别在伤前０．５ｈ、伤后０．５ｈ、１ｈ、２ｈ、３ｈ测量软脑膜微动脉管径和血流速度的变化及伤后３ｈ血液流变学指标。结果表明：大剂量激素在伤后０．５ｈ就能明显地扩张损伤处软脑膜的微动脉并使血流速度明显加快。伤后３ｈ能明显降低血沉、全血粘度、红细胞压积及纤维蛋白原含量，并明显增强红细胞的变形能力，降低其聚集性。这些结果表明大剂量激素能明显改善脑创伤后家兔的脑微循环及血液流变性
In order to investigate the effects of high-dose hormones on cerebral microcirculation and hemorrheology after traumatic brain injury, 24 rabbits were randomly divided into 3 groups: standard control group, injury control group and dexamethasone treatment group. The changes of diameter and velocity of the pia mater microvessels and blood rheology at 3h after injury were measured at 0.5h, 0.5h, 1h, 2h and 3h after injury respectively. The results showed that high-dose hormone could significantly expand the micro-arteries of the lesion at 0.5 h and significantly accelerate the blood flow velocity. 3h after injury can significantly reduce erythrocyte sedimentation rate, whole blood viscosity, hematocrit and fibrinogen content, and significantly enhance the ability of red blood cells to reduce its aggregation. These results indicate that high-dose hormones can significantly improve brain microcirculation and hemorheology in rabbits after traumatic brain injury