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目的:研究食管胃结合部腺癌(adenocarcinoma of the esophagogastric junction,AEG)发病情况的变化趋势。方法:回顾分析2001年1月~2011年12月南京医科大学第一附属医院收治的4 685例胃癌病例,其中AEG1 824例,非食管胃结合部腺癌(non-esophagogastric junction adenocarcinoma,NEGA)2 861例。研究AEG在胃癌中所占比例变化趋势、早期食管胃结合部腺癌(early adenocarcinoma of esophagogastric junction,EAEG)检出率变化趋势、AEG性别年龄分布及比较AEG和NEGA患者发病年龄和性别比的差异。结果:该中心11年来AEG在胃癌中所占比例无明显变化;2007~2011年EAEG的检出率为12.23%(135/1 104),2001~2006年为8.47%(61/720),前者显著高于后者(P=0.013);AEG患者平均发病年龄以及男女性别比均显著高于NEGA患者[(62.7±9.5)岁vs(59.1±12.7)岁,P<0.001;1 434∶390 vs 1 990∶871,P<0.001)]。结论:AEG在胃癌中所占比例无明显增高;近5年EAEG检出率显著增高;AEG好发于男性老年患者。
Objective: To study the changing trend of the incidence of adenocarcinoma of the esophagogastric junction (AEG). Methods: A retrospective analysis of 4 685 cases of gastric cancer admitted to the First Affiliated Hospital of Nanjing Medical University from January 2001 to December 2011 was conducted. Among them, 824 cases of AEG1 and 2 cases of non-esophagogastric junction adenocarcinoma (NEGA) 2 861 cases. To study the trend of the change of the proportion of AEG in gastric cancer, the detection rate of early adenocarcinoma of esophagogastric junction (EAEG), the age distribution of AEG and the age and sex ratio of patients with AEG and NEGA . Results: There was no significant change in the proportion of AEG in gastric cancer over the 11 years. The detection rate of EAEG from 2007 to 2011 was 12.23% (135/1 104) and from 2001 to 2006 (8.47%, 61/720) (P = 0.013). The mean age at onset and the male-female ratio in patients with AEG were significantly higher than those in patients with NEGA [(62.7 ± 9.5) vs (59.1 ± 12.7) years, P <0.001; 4343: 390 vs 1 990: 871, P <0.001)]. Conclusion: The proportion of AEG in gastric cancer has no significant increase; the detection rate of EAEG in the past 5 years is significantly higher; AEG occurs in the elderly male patients.