利什曼素是杜氏利什曼原虫(Leishmania donovani)的鞭毛体经三恩氏培养基培养浓缩制成的一种皮内注射液,用该注射液作皮内注射试验,对已愈或疑似的黑热病患者进行复查,以便肯定或否定。另外也可以用来对不同年令组成的人群作皮内试验,以作出黑热病流行趋势的予测,确定疫区和非疫区。国外于1961年报道了 Manson-Bahr氏用利什曼素对已愈的黑热病患者作皮内试验,证明可以产生阳性反应。我国于1964年也开始了此项研究工作。首先由中国医学科学院上海寄生虫病研究所与山东省寄生虫病防治研究所进行研究。到目前为止,经过十多年的研究,积累了不少资料与经验。我省是 Leishmanin, an intradermal injection of Leishmania donovani flagella grown in three medium cultures, is used as an intradermal injection test to test whether it has healed or suspected Of kala-azar patients for review in order to be positive or negative. In addition, it can also be used to test the skin composition of different age groups in order to make the prediction of the epidemic trend of kala-azar, and to identify the epidemic areas and the non-epidemic areas. Abroad reported in 1961 Manson-Bahr ’s use of Leishmanin for healing kala-azar patients for intradermal test, that can produce a positive reaction. Our country also started this research work in 1964. First, the Chinese Academy of Medical Sciences Shanghai Institute of Parasitic Diseases and Shandong Institute of Parasitic Diseases research. So far, after more than 10 years of research, has accumulated a lot of information and experience. My province is