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目的尝试通过药物溶液的浓度计算其渗透压。方法采用M-NRTL模型,由甘氨酸溶液浓度计算其渗透压,并应用平衡空气法测定溶液的渗透压。结果应用双向单侧t检验法和多重检验调整法进行验证,结果显示M-NRTL模型的计算值与平衡空气法的测定值具有等效性。结论可以应用物理模型由药物溶液的浓度计算渗透压值。
Objective To calculate the osmotic pressure by the concentration of the drug solution. Methods The M-NRTL model was used to calculate the osmotic pressure from the concentration of glycine solution, and the osmotic pressure of the solution was measured by equilibrium air method. The results were verified by two-way one-sided t-test and multiple test adjustment method. The results show that the calculated value of M-NRTL model is equivalent to the measured value of the balance air method. Conclusion The physical model can be used to calculate the osmotic pressure from the concentration of the drug solution.