胎儿血红蛋白(HbF)的产生一直延续到成年,但含量甚少而稳定在一定水平,仅限于小部分红细胞能产生HbF,称之为F-细胞。研究从胎儿到成人血红蛋白所产生转移基因的调节,对异常血红蛋白病的病理生理学和有效的治疗都有重要关系。主要问题在于:是否在胎儿发育的早期阶段存在两种造血干细胞 Fetal hemoglobin (HbF) production continued until adulthood, but the content is low and stable at a certain level, limited to a small part of red blood cells can produce HbF, called F-cells. The study of the regulation of metastasis genes from fetal to adult hemoglobin has an important relationship with the pathophysiology and effective treatment of abnormal hemoglobinopathies. The main question is whether there are two types of hematopoietic stem cells in the early stages of fetal development