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目的··：了解盐酸洛非西定片（ＬＦＸ）控制阿片戒断症状的疗效。方法··：采用随机双盲方法，以美沙酮口服液（Ｍ）作为对照组，进行临床观察比较。结果··：盐酸洛非西定片能有效控制常见的戒断症状；治疗早期Ｍ组效果优于ＬＦＸ组（Ｐ＜０．０１），随着治疗的进行，两药控制戒断症状差异无显著性（Ｐ＞０．０５），而后期ＬＦＸ组效果优于Ｍ组（Ｐ＜０．０１）。不良反应盐酸洛非西定片组出现较多，主要表现为头晕、恶心、口干、乏力等，但随着剂量减少，不良反应也随之缓解。结论··：由于洛非西定本身不具有依赖性，因此是一种值得推广的戒毒药物。
Objective · ·: To understand the efficacy of lobesulfuron hydrochloride tablets (LFX) in controlling opiate withdrawal symptoms. Methods · · ·: A randomized double-blind method to methadone oral solution (M) as a control group for clinical observation and comparison. Results · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · Description: Luoxessine hydrochloride tablets can effectively control the common symptoms of withdrawal; treatment of early M group was better than the LFX group (P <0.01), with the treatment, control withdrawal symptoms (P> 0.05), while the effect of LFX group was better than that of M group (P <0.01). Adverse reactions Loxofeiidine hydrochloride tablets appear more, mainly for dizziness, nausea, dry mouth, fatigue, etc., but with the dose decreased, adverse reactions also will be alleviated. Conclusion ··: Since loxcept is itself not dependent on dependence, it is worth promoting a drug addiction treatment.