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目的高强度聚焦超声(HIFU)是治疗恶性实体肿瘤的新方法,本文主要探讨HIFU联合TACE治疗恶性肿瘤的近期临床疗效。方法本文观察了19例HIFU联合TAE/TACE治疗恶性实体肿瘤,14例术中B超监测出现明显回声增强。根据患者术前后的临床症状、B超、肝功能检查、AFP、MRI等评价HIFU的临床疗效。结果术后AFP呈不同程度下降,MRI示肿瘤体内血供减少,肿瘤有不同程度坏死,部分瘤体直径缩小。仅少数患者有轻度的局部烧伤,无一例严重并发症。结论HIFU对实体肿瘤有确切疗效,TAE/TACE和HIFU在肿瘤治疗中有协同作用,新鲜碘油沉积可能在其中起较大作用。
Objective High intensity focused ultrasound (HIFU) is a new method for the treatment of malignant solid tumors. This article mainly discusses the recent clinical efficacy of HIFU in combination with TACE in the treatment of malignant tumors. Methods Twenty-nine HIFU combined with TAE / TACE in the treatment of malignant solid tumors were observed in this study. Echo enhancement was observed in 14 cases of B-ultrasound. The clinical efficacy of HIFU was evaluated according to the clinical symptoms, B-ultrasound, liver function test, AFP and MRI before and after the operation. Results Postoperative AFP decreased to varying degrees. MRI showed reduced blood supply to the tumor, necrosis of the tumor to some extent, and reduction of the diameter of some tumors. Only a small number of patients with mild local burn, without a serious complication. Conclusion HIFU has definite curative effect on solid tumors. TAE / TACE and HIFU have synergistic effect in the treatment of tumors, and fresh lipiodol deposition may play a significant role in them.