癌基因ｃ -ｅｒｂＢ - 2的扩增和抗癌基因Ｐ53的突变是肿瘤中较为常见的基因改变 ,通常导致基因蛋白产物表达质和量的变化。我们应用免疫组化法对 55例乳腺癌组织连续切片 ,同步进行癌基因ｃ -ｅｒｂＢ - 2和抗癌基因Ｐ53表达的研究 ,探讨这二种癌基因蛋白在乳腺癌发生发展中的 Amplification of the oncogene c-erbB-2 and mutation of the anti-oncogene P53 are the more common genetic alterations in tumors, often resulting in changes in the quality and quantity of the gene protein product. We applied immunohistochemistry to serial sections of 55 cases of breast cancer and simultaneously studied the expression of oncogene c-erbB-2 and anti-oncogene P53, and explored the roles of these two oncogenes in the development of breast cancer