目的 :探讨颅底及咽旁间隙肿瘤切除的最佳手术入路。 方法 :2例咽旁间隙肿瘤、1例颅底肿瘤患者均采用上颌骨外旋入路 ,取Weber Ferguson Longmire切口 ,形成以咬肌为蒂的上颌骨肌皮瓣并外旋 ,充分暴露鼻咽部及咽旁间隙 ,直视下完整切除肿瘤。以颊部脂肪堵塞残留空腔 ,行上颌骨骨瓣复位。结果 :3例术后切口愈合良好 ,颌面部无明显畸形及颌面功能障碍 ,其中 1例术后行放疗。 3例术后随访 10个月～ 2年 ,肿瘤均无复发。结论 :上颌骨外旋是切除颅底及咽旁间隙肿瘤的较佳手术入路 ,能充分暴露颅底及咽旁间隙、鼻咽部 ,在直视下完整分离切除肿瘤 ,手术安全 ,损伤小 ,术后功能恢复良好。 Objective: To explore the best surgical approach for tumor resection in skull base and parapharyngeal space. Methods: Two cases of parapharyngeal space tumor and one case of skull base tumor were treated by maxillary remodeling. Weber Ferguson Longmire incision was used to form maxillary myocutaneous flap pedicled with masseter muscle and external rotation, which fully exposed the nasopharynx Department and parapharyngeal space, complete resection of the tumor under direct vision. To cheek fat block the residual cavity, line maxillary bone flap reduction. Results: The incision healed well in 3 cases. There was no obvious deformity and maxillofacial dysfunction in maxillofacial region. One case was treated with radiotherapy. Three patients were followed up for 10 months to 2 years, no recurrence of the tumor. CONCLUSION: Maxillary external rotation is the best surgical approach to resect the skull base and parapharyngeal space tumor. It can fully expose the skull base and parapharyngeal space, nasopharynx and completely separate and remove the tumor under direct vision. The operation is safe and the damage is small Postoperative functional recovery is good.