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目的探讨急性缺血性脑血管病患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)与急性缺血性脑血管病的关系。方法急性缺血性脑血管病患者126例,其中短暂性脑缺血发作(TIA)患者35例,急性脑梗死患者91例,分为轻、中、重度脑梗死组。应用ELISA法测定标本中Lp-PLA2水平。结果 Lp-PLA2含量在脑梗死组(47.697±23.865)μg/L明显高于TIA组(31.973±22.078)μg/L(P<0.01);且轻、中度脑梗死组与重度脑梗死组比较差异有统计学意义(P<0.05)。结论血浆Lp-PLA2随缺血性脑血管病严重程度的增加逐渐升高,可能是判断病情严重程度的指标之一。
Objective To investigate the relationship between plasma lipoprotein associated phospholipase A2 (Lp-PLA2) and acute ischemic cerebrovascular disease in patients with acute ischemic cerebrovascular disease. Methods 126 cases of acute ischemic cerebrovascular disease, including 35 cases of transient ischemic attack (TIA), 91 cases of acute cerebral infarction, divided into mild, moderate and severe cerebral infarction group. The level of Lp-PLA2 in the specimens was determined by ELISA. Results The level of Lp-PLA2 in cerebral infarction group (47.697 ± 23.865) μg / L was significantly higher than that in TIA group (31.973 ± 22.078) μg / L (P <0.01). Compared with severe cerebral infarction group, The difference was statistically significant (P <0.05). Conclusions Plasma Lp-PLA2 gradually increases with the severity of ischemic cerebrovascular disease, which may be one of the indicators to judge the severity of the disease.