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本文报告了对７８只大白鼠同１２只家兔人工创伤颌面部软组织及使下颌骨粉碎性骨折。动态观察伤前及伤后３０分钟，１、２、４、６及１２小时的ＬＰＯ、ＳＯＤ的改变。检测创伤后不论在血中，创伤组织或肝组织中，均为ＬＰＯ上升，ＳＯＤ下降，ＳＯＤ／ＬＰＯ比值下降。受伤早期大剂量使用维生素Ｃ抗氧化治疗，能够抑制ＬＰＯ的合成，增加ＳＯＤ／ＬＰＯ的比值，并能提高机体的代偿能力，对机体的结构组织有一定的保护作用。作者对创伤后ＬＰＯ改变的临床意义、ＳＯＤ的作用机制、抗氧化治疗及维生素Ｃ的应用价值等问题进行了讨论。
This paper reports the soft tissue of the maxillofacial region and the comminuted mandibular fracture of 78 rabbits and 12 rabbits. Dynamic observation of pre-injury and 30 minutes after injury, 1,2,4,6 and 12-hour LPO, SOD changes. No matter in the blood, trauma or liver tissue, LPO increased, SOD decreased and the ratio of SOD / LPO decreased after trauma. Early use of high doses of vitamin C anti-oxidant therapy can inhibit the synthesis of LPO, increase the ratio of SOD / LPO, and can improve the body's compensatory capacity of the body's structure and organization have a protective effect. The authors discuss the clinical significance of the changes of LPO after trauma, the mechanism of action of SOD, anti-oxidation therapy and the value of vitamin C application.