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研究白藜芦醇对小鼠柯萨奇病毒感染性心肌炎的干预作用并探讨其作用机制。制作柯萨奇病毒感染性心肌炎小鼠动物实验模型 ,采用病毒唑、黄芪注射液和黄芪煎液作为中西药物治疗对照 ,观察白藜芦醇腹腔内注射和经饮水给药对模型小鼠的一般情况、生存率、心肝脾形态等变化 ,及血清丙二醛 (MDA)、一氧化氮 (NO)等生化指标及心脏组织病理学的影响。结果 :与病毒唑、黄芪注射液和黄芪煎液相比 ,白藜芦醇对柯萨奇病毒感染性心肌炎小鼠的一般情况、生存率、心肝脾变化、血清MDA和NO等生化指标及心脏组织病理学均有良好的改善作用。提示 :白藜芦醇对小鼠柯萨奇病毒感染性心肌炎有良好的拮抗作用。
To study the effect of resveratrol on the coxsackievirus-infective myocarditis in mice and its mechanism of action. A mouse experimental animal model of Coxsackie virus-infected myocarditis was prepared. Ribavirin, Huangqi injection and Huangqi decoction were used as Chinese and Western drug control to observe the effects of intraperitoneal injection and drinking water administration of resveratrol on model mice. Changes in conditions, survival rates, heart, liver, spleen, and other biochemical indicators such as serum malondialdehyde (MDA), nitric oxide (NO), and cardiac histopathology. RESULTS: Compared with ribavirin, astragalus injection and astragalus decoction, resveratrol had general conditions, survival rate, heart and liver and spleen changes, serum MDA and NO biochemical indicators, and heart in mice with Coxsackie virus-infected myocarditis. Histopathology has a good improvement. Reminder: Resveratrol has a good antagonism against Coxsackie virus-induced myocarditis in mice.