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目的探讨吡喹酮治疗对日本血吸虫病患者血清抗幽门螺杆菌HpIgG水平的影响。方法利用Hp全菌抗原对流行区94例日本血吸虫病人治疗前后血清抗HpIgG进行检测。结果治疗后3、6个月，Hp感染阳性率分别为73.4％和70.2％(治疗前为75.5％)，HpIgG抗体水平分别为0.71±0.30和0.65±0.21(治疗前为0.80±0.23)，对照组均有轻度升高。各年龄组Hp感染阳性率和血清HpIgG水平均随治疗进展而降低，其中0～20岁年龄组血清HpIgG下降最快。血清抗HpIgG和同期对应的日本血吸虫31／32kDa(Sj31／32)IgG抗体平均水平及阴转值之间高度相关(治疗后3个月r分别为0.85和0.65，治疗后6个月r分别为0.85和0.50)。结论日本血吸虫病人经吡喹酮治疗后Hp感染阳性率及血清HpIgG水平降低，日本血吸虫与Hp感染高度相关，血吸虫可能作为Hp感染的危险因素之一。“,”Aim To study the effects of praziquantel treatment on the level of Helicobacter pylori(Hp) antibody in patients infected Schistosoma japonicum. Methods The whole cell antigen of Hp was used to detect the Hp IgG antibody in 94 cases of sera from the patients before and after praziquantel treatment. Results The positive Hp infection rate was 73.4％ and 70. 2％ respectively (75.5％ before treatment) after treatment for 3 and 6 months. The level of Hp IgG was 0.71±-0. 30 and 0. 65±0. 21 (0. 80±0. 23 before treatment)respectively. The Hp positive rate and the level of Hp IgG declined with the process of treatment in all age groups,but the Hp IgG level dropped the most quickly in the age group of 0～20. The level and the dropped value of Hp IgG were related to that of Sj31/32 IgG(0. 85 and 0. 65,0. 80 and 0. 50 after treatment for 3 and 6 months). Conclusion The results indicated that the praziquantel treatment can reduce the positive rate and the level of Hp IgG in patients of Schistosoma japonicum. There was a significant correlation between Schistosoma japonicum and Hp infec tion. Schistosoma japonicum might be one of the risk factors of Hp infection.