目的探讨在外周介入治疗中应用NBCA/Glubran-2胶的临床经验。方法 112例患者共184处部位应用NBCA/Glubran-2胶栓塞治疗,根据病变性质分为动脉性(外周动脉病变)、静脉性(食道胃底静脉曲张及门静脉)及肝脾穿刺道三类,其中外周动脉病变19例,静脉性93例(胃底静脉曲张80例,门静脉13例),肝脾穿刺道72例。根据病变血流速度及血流量不同,配制NBCA/Glubran-2胶与超液化碘油比例为1:2-1:4,对于血流速度较快、血流量较大者,预先用弹簧圈或球囊阻断部分血流后再行组织胶栓塞。根据并发症的严重程度分为轻度和重度并发症,统计此三类病变介入治疗中并发症的差异。结果三类病变(动脉性、静脉性、穿刺道)栓塞有效率分别为100%(19/19)、92.5%(86/93)、100%(72/72)。并发症总例数为16例(8.7%),其中重度并发症3例,分别为肺栓塞、下肢缺血坏死及肠缺血坏死各1例,轻度并发症13例。三类病变并发症发生率存在统计学差异,由高至低为:动脉性(21.1%)、静脉性(10.8%)、穿刺道(2.8%)。结论在外周病变应用NBCA胶/Glubran-2胶栓塞治疗是一种安全有效的方法,掌握病变的血流特性能提高栓塞治疗的有效率,降低并发症发生率。 Objective To investigate the clinical experience of using NBCA / Glubran-2 glue in peripheral interventional therapy. Methods A total of 184 sites of 112 patients were treated with NBCA / Glubran-2 glue plug. According to the nature of the disease, they were divided into arterial (peripheral artery disease), venous (esophageal varices and portal vein) Including 19 cases of peripheral artery disease, venous 93 cases (80 cases of gastric varices, portal vein 13 cases), 72 cases of liver and spleen puncture. According to the lesion blood flow rate and blood flow, the preparation of NBCA / Glubran-2 glue and liquefied iodized oil ratio of 1: 2-1: 4, for faster blood flow, blood flow larger who pre-use coil or Balloon block part of the blood flow and then tissue glue plug. According to the severity of complications were divided into mild and severe complications, statistical intervention in these three categories of complications in the difference. Results The effective rates of embolization in three kinds of diseases (arterial, venous and puncture) were 100% (19/19), 92.5% (86/93) and 100% (72/72), respectively. The total number of complications was 16 cases (8.7%), of which 3 cases of severe complications were pulmonary embolism, ischemic necrosis of the lower limbs and intestinal ischemia necrosis in 1 case, 13 cases of mild complications. There was a statistically significant difference in the incidence of complications between the three groups, ranging from high to low: arterial (21.1%), venous (10.8%) and puncture (2.8%). Conclusion The application of NBCA glue / Glubran-2 glue embolization in peripheral lesions is a safe and effective method. To master the blood flow characteristics of the lesions can improve the efficiency of embolization and reduce the incidence of complications.