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目的:评估病态肥胖患者在低热量饮食和浸浴治疗前后,C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)以及胰岛素抵抗指数(HOMA-IR)的水平变化。创新点:研究炎症反应对病态肥胖的影响。方法:本研究包括33个病例和20个正常对照,对治疗前后的CRP、IL-6、TNF-α、血脂谱、HOMA-IR以及空腹血糖水平进行评估。结论:与对照组相比,低热量饮食和浸浴治疗后,病态肥胖患者的CRP水平显著降低,而TNF-α和IL-6的水平却没有显著变化,这表明脂肪细胞的正常功能恢复之前必须先去除一定量的脂肪组织。HOMA-IR水平的降低说明对胰岛素的敏感性有所提高,这有利于肥胖患者的治疗。
OBJECTIVE: To assess the changes of CRP, TNF-α, IL-6 and HOMA-1 in patients with morbid obesity before and after low-calorie diet and bathing therapy. IR) level changes. Innovation: To study the impact of inflammatory response on morbid obesity. Methods: This study included 33 cases and 20 normal controls. CRP, IL-6, TNF-α, lipid profile, HOMA-IR and fasting blood glucose levels before and after treatment were evaluated. CONCLUSIONS: CRP levels were significantly reduced in patients with morbidly obese subjects but not significantly different from those in control subjects after low-calorie diet and bathing therapy, indicating no significant changes in the levels of TNF-α and IL-6 A certain amount of fat tissue must be removed first. The reduction in HOMA-IR levels suggests an increased sensitivity to insulin, which is beneficial for the treatment of obese patients.