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目的探讨滋阴益气中药减少老年患者肾病综合征复发的临床疗效。方法选择2012年12月至2014年8月在石家庄肾病医院接受治疗的初诊90例老年肾病综合征患者,按照随机数字表法分为治疗组和对照组,每组45例,对照组采用西医常规治疗,治疗组在对照组的基础上增加滋阴益气汤口服治疗,观察患者用药后的临床疗效和18个月的复发情况,定期检测尿常规、24h尿蛋白定量、血清清蛋白、血脂7项、肌酐等。结果治疗6个月后,治疗组总有效率为90.48%,对照组总有效率为60.09%,2组比较差异有统计学意义(χ~2=5.973,P=0.015)。治疗12、18个月后,治疗组患者的复发率均低于对照组,差异有统计学意义(P<0.05)。治疗后2组患者的尿素氮、24h尿蛋白定量、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、血肌酐等均低于治疗前,而血清总蛋白、血清清蛋白、高密度脂蛋白胆固醇高于治疗前,且治疗组优于对照组,差异有统计学意义(P<0.05)。结论滋阴益气中药可提高老年患者肾病综合征的临床疗效,显著降低患者的复发率,改善尿常规、24h尿蛋白定量、清蛋白、血脂7项、肌酐等指标。
Objective To explore the clinical efficacy of Chinese herbs for nourishing yin and strengthening qi to reduce relapse of nephrotic syndrome in elderly patients. Methods A total of 90 newly diagnosed nephrotic syndrome patients treated in Shijiazhuang Nephropathy Hospital from December 2012 to August 2014 were randomly divided into treatment group and control group according to the random number table method, with 45 cases in each group. The control group was treated with routine western medicine The treatment group and the treatment group were treated with Ziyin Yiqi Decoction orally on the basis of the control group. The clinical curative effect and recurrence after 18 months were observed. Urine routine examination, 24 h urine protein quantitation, serum albumin, serum lipid 7 Items, creatinine and so on. Results After 6 months of treatment, the total effective rate was 90.48% in the treatment group and 60.09% in the control group. The difference between the two groups was statistically significant (χ ~ 2 = 5.973, P = 0.015). After treatment for 12 and 18 months, the recurrence rate in the treatment group was lower than that in the control group, with significant difference (P <0.05). After treatment, the blood urea nitrogen, 24-hour urinary protein, total cholesterol, triglyceride, low density lipoprotein cholesterol and serum creatinine in the two groups were lower than those before treatment, while serum total protein, serum albumin, high density lipoprotein cholesterol Higher than before treatment, and the treatment group than the control group, the difference was statistically significant (P <0.05). Conclusion Nourishing Yin Qi Chinese medicine can improve the clinical efficacy of nephrotic syndrome in elderly patients, significantly reduce the recurrence rate, improve urine routine, 24h urinary protein, albumin, serum lipids, creatinine and other indicators.