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低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)作为目前发现的具有高度特异性感受细胞氧分压的调节因子,在脑损伤发生、发展过程中发挥着重要的双向调节作用。HIF-1在轻度和中度脑损伤过程中可以增加神经细胞耐受,促进存活;在重度损伤时,参与细胞凋亡途径,促进神经细胞死亡,在脑损伤中发挥重要作用。对HIF-1及其信号通路的深入研究可为脑损伤的治疗提供药物作用靶点,有重要的理论研究和实用价值。现就HIF-1的结构、功能及在脑损伤中的调节作用进行综述,为临床治疗脑损伤提供参考。
Hypoxia-inducible factor-1 (HIF-1), as a regulator of the oxygen partial pressure in cells with highly specific sensitivity, has been shown to play an important bidirectional role in the development and progression of brain injury . HIF-1 can increase neural cell tolerance and promote survival in mild and moderate brain injury. In severe injury, HIF-1 participates in the apoptotic pathway and promotes neuronal cell death, playing an important role in brain injury. In-depth study of HIF-1 and its signaling pathways can provide a drug target for the treatment of brain injury, which has important theoretical research and practical value. HIF-1 is now on the structure, function and regulatory role in brain injury are reviewed for clinical treatment of brain injury provide a reference.