肿瘤的生物标志物研究对肿瘤的早期诊断和治疗有重要意义。虽然前列腺特异性抗原(PSA)用于临床前列腺癌的筛查和治疗效果评价已经20余年,但是其效果并不能完全让人满意。随着对前列腺癌研究的深入,目前已经发现了多种前列腺癌的生物标志物。本文就前列腺癌生物标志物筛查的临床研究进展进行综述。 Tumor biomarker research on the early diagnosis and treatment of cancer is of great significance. Although prostate-specific antigen (PSA) has been used in the screening and treatment of clinical prostate cancer for more than 20 years, its efficacy has not been entirely satisfactory. With the further research on prostate cancer, a variety of biomarkers of prostate cancer have been discovered. This article reviews the progress of clinical research on the screening of prostate cancer biomarkers.