论文部分内容阅读
本文报道了一种含有融合蛋白Lam B-前S2的重组细菌株(pop6510)诱导小鼠产生免疫应答的情况.作者发现静脉注射(IV)途径对重组细菌表达的抗原引起的免疫应答具有重要意义.静脉接种Balb/c小鼠第1针后两周就出现前S2多肽抗体,第2针后抗体水平更高.然而笫1针后没有出现抗-HBs,而在第2针后出现高水平抗-HBs.皮下接种(SC)2针后抗多肽和抗-HBs均未出现,即使第3针用5×10~8菌体和1mg Al(OH)_3作SC后,
In this paper, we report the immunogenic response induced by a recombinant bacterial strain (pop6510) containing the fusion protein Lam B-preS2 and found that the intravenous (IV) route is important for the immune response elicited by recombinant bacteria expressed antigens Pre-S2 peptide antibody appeared two weeks after intravenous inoculation of Balb / c mouse, and the antibody level was higher after the second needle.However, there was no anti-HBs after the first needle, but high level after the second one Anti-HBs. Subcutaneous inoculation (SC) 2-pin post-anti-peptide and anti-HBs did not appear, even if the third needle with 5 × 10 8 cells and 1mg Al (OH)