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目的探讨分析多种西药合用的不良反应发生原因,为临床合理用药提供理论参考。方法对我院2014年1月至2015年10月开具的2915份西药合用的处方进行回顾性分析,在统计良反应类型的基础上分析发生不良反应的原因,以制定科学的措施促进临床合理用药。结果 2915份西药合用的处方中,169例患者发生不良反应,不良反应发生率为5.8%。其中不良反应类型包括恶心呕吐、身体冷热交替、头晕头痛、胃部疼痛、水肿、皮肤过敏,发生率分别为42.3%、20.7%、20.1%、14.2%、12.4%、7.1%;发生不良反应的原因包括:西药用法以及用量不当、西药配伍不当、给药方式错误、其它因素,发生率分别30.8%、32.5%、29.6%、7.1%。结论多种西药联合使用产生不良反应的原因包括用法以及用量不当、配伍不当、给药方式错误等,临床实践中要以此为基础采取针对性的措施进行干预,以促进合理用药。
Objective To analyze and analyze the causes of adverse reactions combined with various western medicines and to provide a theoretical reference for clinical rational use of drugs. Methods A retrospective analysis of 2,915 prescriptions for western medicine issued from January 2014 to October 2015 in our hospital was conducted. The causes of adverse reactions were analyzed on the basis of statistical good response types so as to formulate scientific measures to promote clinical rational use of drugs . Results Among the 2915 prescriptions of western medicine, 169 patients developed adverse reactions with a rate of adverse reactions of 5.8%. The adverse reaction types included nausea and vomiting, body alternating of hot and cold, dizziness, headache, stomach pain, edema and skin allergy. The incidence rates were 42.3%, 20.7%, 20.1%, 14.2%, 12.4% and 7.1% The reasons include: the use of western medicine as well as the inappropriate dosage, inappropriate compatibility of western medicine, administration errors, other factors, the incidence rates were 30.8%, 32.5%, 29.6%, 7.1%. Conclusions The causes of adverse reactions caused by the combination of multiple western medicines include usage, improper dosage, improper compatibility and incorrect administration methods. In clinical practice, we should take targeted measures to intervene in order to promote rational drug use.