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采用放射免疫法测定67例肾小球疾病患儿尿微量白蛋白(尿 Alb)含量,其中46例作肾活检。结果肾病综合征组与紫癜性肾炎组尿 Alb 含量均明显大于正常对照组(P<0.01),急性肾炎组尿 Alb 亦增高(P<0.05),单纯性血尿与过敏性紫癜组与正常对照无差异(P>0.05),2例慢性肾炎伴慢性肾衰者尿 Alb 均属正常。提示尿 Alb 含量与原有疾病性质、临床类型及其肾小球基底膜通透性改变的程度有关。尿 Alb 含量与病理形态学及肾功能改变无相关性。
Radioimmunoassay was used to detect urinary albumin (ALB) in 67 cases of glomerular diseases, of which 46 cases were used for renal biopsy. Results Urinary Alb levels in nephrotic syndrome group and purpuric nephritis group were significantly higher than those in normal control group (P <0.01), urinary Alb in acute nephritis group was also increased (P <0.05), simple hematuria and anaphylactoid purpura group (P> 0.05). Urinary Alb in two chronic nephritis patients with chronic renal failure were normal. Urinary Alb content prompted the nature of the original disease, clinical types and the degree of glomerular basement membrane permeability changes. Urine Alb content and pathological morphology and renal function had no correlation.