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目的分析急性胰腺炎(AP)合并肝功能不全的临床特点、预后和防治措施。方法回顾性分析2006年1月至2008年12月我院收治的145例AP患者,其中53例合并肝功能不全,92例肝功能正常。对比分析两组患者的病因、血液生化指标、并发症、病程等相关因素。结果AP肝功能不全组病因中胆源性疾病明显高于AP肝功能正常组(P<0.05)。两组间肾功能不全、心脏损伤的比较差异无统计学意义(P>0.05)。AP肝功能不全组血、尿淀粉酶明显高于AP肝功能正常组(P<0.05),其病程较AP肝功能正常组延长(P<0.05)。结论AP合并肝功能不全与AP引起的机体内环境紊乱以及解剖因素有关,肝功能不全加重AP病情,延长病程。积极治疗原发病同时保肝治疗对于恢复肝功能、缩短病程有重要意义。
Objective To analyze the clinical features, prognosis and prevention and treatment of acute pancreatitis (AP) complicated with hepatic insufficiency. Methods A retrospective analysis of 145 cases of AP patients admitted from January 2006 to December 2008 in our hospital, of which 53 cases with hepatic insufficiency, 92 cases of normal liver function. Comparative analysis of two groups of patients etiology, blood biochemical indicators, complications, duration and other related factors. Results The cause of gallstone disease in AP hepatic insufficiency group was significantly higher than that in normal liver function group (P <0.05). There was no significant difference in renal insufficiency and cardiac injury between the two groups (P> 0.05). The serum and urine amylase of AP hepatic dysfunction group was significantly higher than that of AP normal liver function group (P <0.05), and its duration was longer than that of AP normal liver function group (P <0.05). Conclusion AP complicated with liver dysfunction and AP caused by environmental disorders and anatomical factors, liver dysfunction aggravate AP disease, prolong the course of the disease. Active treatment of primary disease while liver protection for the restoration of liver function, shorten the course of great significance.