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目的比较中成药康艾注射液联合5-FU、奥沙利铂与单用化疗对大肠癌术后的临床疗效。方法大肠癌术后患者,随机分组为治疗组(中成药+化疗)和对照组(化疗)。各组均治疗4-6个疗程,观察生活质量和毒副反应的同时,比较复发时间、复发率、1-3年生存率和中位生存期。结果治疗组在改善临床症状和毒副反应明显优于对照组(P<0.05),但在1￣2年生存期比较差异无意义(P>0.05),而在累计死亡率、3年生存期、中位生存期以及复发率等方面差异均有显著性意义(P<0.05)。结论中成药康艾注射液可明显改善大肠癌患者生活质量和减少化疗药物毒副反应,并对术后患者可延长生命和减少复发,可见选择中成药配合化疗是很有意义的临床治疗方案。
Objective To compare the clinical effects of Kangai injection combined with 5-FU, oxaliplatin and chemotherapy alone on postoperative colorectal cancer. Methods Colorectal cancer patients were randomly divided into treatment group (Chinese patent medicine + chemotherapy) and control group (chemotherapy). Each group were treated 4-6 courses, quality of life and side effects were observed at the same time, the recurrence rate, recurrence rate, 1-3 years of survival and median survival. Results The treatment group was significantly better than the control group in improving clinical symptoms and adverse reactions (P <0.05), but the difference was not significant in 1 ~ 2 years of survival (P> 0.05), while in the cumulative mortality, 3 years of survival , Median survival and relapse rate were significantly different (P <0.05). Conclusion Chinese medicine Kangai injection can significantly improve the quality of life of patients with colorectal cancer and reduce the side effects of chemotherapy drugs, and postoperative patients can prolong life and reduce recurrence, shows the choice of proprietary Chinese medicine with chemotherapy is a very meaningful clinical treatment.