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目的评价肝细胞肝癌(hepatocellular carcinoma,HCC)原位肝移植后的预后相关因素。方法回顾性分析1993年11月到2006年5月期间汉诺威医科大学对117例HCC进行肝移植的经验。结果经多因素分析,肿瘤大小和肿瘤数量(米兰标准或加州标准)、微血管侵犯、移植前治疗和肿瘤复发是影响患者生存预后的重要因素。结论原位肝移植是治疗HCC的理性术式;合适的选择标准,积极的移植前治疗,复发的有效控制,是患者获得良好预后的关键。
Objective To evaluate the prognostic factors of orthotopic liver transplantation of hepatocellular carcinoma (HCC). Methods The clinical data of 117 HCC patients who underwent liver transplantation from November 1993 to May 2006 were analyzed retrospectively. Results Multivariate analysis showed that tumor size and number of tumors (Milan standard or California standard), microvascular invasion, pre-transplant treatment and tumor recurrence were the important factors affecting the prognosis of patients. Conclusion orthotopic liver transplantation is the rational surgical treatment of HCC. The appropriate selection criteria, positive pre-transplant treatment, and effective control of recurrence are the keys to achieving a good prognosis.