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目的 为观察双倍剂量雷公藤多甙对儿童原发性肾病综合征的疗效。方法 对住院明确病理类型的４６ 例原发性肾病综合征患儿，用雷公藤多甙（２ ｍｇ／ｋｇ ．ｄ） 治疗４ 周，随之减半量维持。结果 在治疗期间，３５ 例患儿获得缓解（ 缓解率７６１ ％ ） ，９ 例患儿改善，总有效率达９５７ ％ 。其中 Ｍ Ｃ Ｎ Ｓ（１１ 例） ， Ｍｓ Ｐ Ｇ Ｎ（２７ 例） ， Ｍ Ｐ Ｇ Ｎ（５ 例） ， Ｍ Ｎ（３ 例） 的缓解率分别为８１８ ％ ，８１５ ％ ，６００ ％ ，３３３ ％ 。随访３ 个月内未见复发。结论 由于病理类型不同疗效相差较大，临床上对激素治疗无效或耐药的原发性肾病综合征者，应及时行肾活检以明确病理诊断，对病理类型为 Ｍ Ｃ Ｎ Ｓ、 Ｍｓ Ｐ Ｇ Ｎ 和 Ｍ Ｐ Ｇ Ｎ 者，可单用双倍剂量雷公藤多甙治疗，以避免长期服用激素的副作用，是治疗儿童原发性肾病综合征的有效方法之一。
Objective To observe the double dose of tripterygium glycosides in children with primary nephrotic syndrome curative effect. Methods Forty-six children with primary nephrotic syndrome who were hospitalized with definite pathological type were treated with tripterygium glycosides (2 mg / kg · d) for 4 weeks and then reduced by half. Results During the treatment period, 35 children were relieved (remission rate 76.1%), 9 children improved, the total effective rate was 95.7%. The response rates of M C N S (11 cases), Ms P G N (27 cases), M P G N (5 cases) and M N (3 cases) were 818%, 815%, 60 0%, 33 3%. Follow-up within 3 months no recurrence. Conclusion Due to the different pathological types of different effects of large clinical clinically ineffective or resistant to steroid therapy in patients with primary nephrotic syndrome should prompt renal biopsy to clear the pathological diagnosis of pathological types M C N S, Ms P G N and M P G N, single double dose of tripterygium glycosides treatment, in order to avoid long-term side effects of hormones is to treat children with primary nephrotic syndrome is an effective method.