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目的:研究R-型钙通道阻滞剂SNX-482对大鼠自发性蛛网膜下隙出血(SAH)脑血流量减少的改善作用,并与L-型钙通道阻滞剂尼莫地平进行比较。方法:建立大鼠鞍上池SAH模型,分为SAH组、SAH+尼莫地平组、SAH+SNX-482组和假手术组。SAH+尼莫地平组和SAH+SNX-482组分别于模型建立后第1、2天向脑池内注射尼莫地平5μg或SNX-482 5μg,第3天行神经功能评分、荧光微球法测定脑血流量以及脑组织大体病理观察。结果:SAH大鼠模型,据Sugawara大鼠SAH病理分级为中度。3组间神经功能评分差异无统计学意义(P>0.05);尼莫地平对脑血流量下降无明显治疗作用(P>0.05);SNX-482可减少SAH引起的脑血流量下降(P<0.05)。结论:R-型钙通道阻滞剂很可能成为有效的SAH脑血管痉挛治疗药物。
AIM: To investigate the effect of SNX-482, an R-type calcium channel blocker, on the decrease of cerebral blood flow in spontaneous subarachnoid hemorrhage (SAH) rats and to compare with L-type calcium channel blocker nimodipine . Methods: SAH model of rat saddle cistern was established and divided into SAH group, SAH + nimodipine group, SAH + SNX-482 group and sham operation group. SAH + nimodipine group and SAH + SNX-482 group were injected with nimodipine 5μg or SNX-482 5μg on the 1st and 2nd day after model establishment respectively. The nerve function score was measured on the 3rd day and the brain Blood flow and brain tissue gross pathology. Results: SAH rat model, according to Sugawara rat SAH pathological grade was moderate. There was no significant difference in neurological function scores between the three groups (P> 0.05). Nimodipine had no significant effect on the decrease of cerebral blood flow (P> 0.05). SNX-482 could reduce the decrease of cerebral blood flow induced by SAH (P < 0.05). Conclusion: R-type calcium channel blockers are likely to be effective agents for the treatment of SAH-induced cerebral vasospasm.